Monitor Carefully (1)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Mitotane is often a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for feasible dosage adjustments.Remedies are generally not encouraged, on condition that Unintended eff